Specimen: 2 mL (1 mL min.) serum from 1 SST. Ship refrigerated or frozen. An early morning specimen is preferred.
Stability (Room): N/A
Stability (Refrigerated): 4 days
Stability (Frozen): 4 weeks
Comment: Also see 17-HYDROXY-PROGESTERONE STIMULATION BY ACTH and STEROID PANEL FOR CONGENITAL ADRENAL HYPERPLASIA. LC-MS/MS is the gold standard for steroid hormone assays due to increased sensitivity & specificity as compared to immunoassays. Endocrine Society Clinical Practice Guidelines (2018) recommends second tier screen by LCMS/MS
Price: Contact Medilab
Turnaround time (TAT): 7 – 15 days
Usage: The analysis of 17-hydroxyprogesterone (17-OHP) is 1 of the 3 analytes along with Cortisol and Androstenedione that constitutes the best screening test for Congenital Adrenal Hyperplasia (CAH), caused by either 11- or 21-hydroxylase deficiency. Analysis for 17-OHP is also useful as part of a battery of tests to evaluate females with hirsutism or infertility; both can result from adult-onset CAH.
Disease: Disorders of Adrenal Gland
Home Collection: Available
Pre-test Information: An early morning specimen is preferred.