Test CatalogueFISH: BCR / ABL OR PHILADELPHIA TRANSLOCATION

Specimen: 5 mL (3 mL min.) Whole blood OR 4 mL ( 2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

Stability (Room): 48 hrs

Stability (Refrigerated): N/A

Stability (Frozen): N/A

Method: FISH

Comment: Samples received on holidays will be reported in next schedule / next working day.

Price: Contact Medilab

Turnaround time (TAT): 10 – 15 days

Usage: The t(9;22) is a balanced translocation between chromosomes 9 & 22 leading to fusion of bcr & c-abl genes and to the transcription of leukemia specific bcr-abl mRNAs. Philadelphia (Ph) chromosome causing the BCR/ABL fusion, is present in approximately 95% cases of Chronic myeloid leukemia (CML) and 25-30% cases of Acute lymphoblastic leukemia (ALL). Due to development of potent tyrosine kinase inhibitors & anti-sense therapies, presence of BCR/ABL translocation is a favorable prognostic marker.

Specialty: Oncologist, Hematologist

Disease: Leukemia

Components:

Courier Charges:

Home Collection: Not Available

Department: CYTOGENETICS

Pre-test Information: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

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