Specimen: 5 mL (3 mL min.) Whole blood OR 4 mL ( 2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Stability (Room): 48 hrs
Stability (Refrigerated): N/A
Stability (Frozen): N/A
Comment: Samples received on holidays will be reported in next schedule / next working day.
Price: Contact Medilab
Turnaround time (TAT): 10 – 15 days
Usage: The t(9;22) is a balanced translocation between chromosomes 9 & 22 leading to fusion of bcr & c-abl genes and to the transcription of leukemia specific bcr-abl mRNAs. Philadelphia (Ph) chromosome causing the BCR/ABL fusion, is present in approximately 95% cases of Chronic myeloid leukemia (CML) and 25-30% cases of Acute lymphoblastic leukemia (ALL). Due to development of potent tyrosine kinase inhibitors & anti-sense therapies, presence of BCR/ABL translocation is a favorable prognostic marker.
Specialty: Oncologist, Hematologist
Home Collection: Not Available
Pre-test Information: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.