Specimen: 50 mL (10 mL min.) aliquot of 24-hour urine. Add 50% HCl drop by drop to bring the pH between 1–2. Do not use concentrated HCl. Ship refrigerated or frozen. Patient should strictly avoid L-Dopa at least 72 hours before and during collection.
Stability (Room): 8 hrs
Stability (Refrigerated): 7 days
Stability (Frozen): 30 days
Comment: Initial testing for Pheochromocytoma should always include measurement of plasma free metanephrines or urinary fractionated metanephrines or both. Recommended method to measure is LC-MS/MS OR HPLC-EC. Also see NEURONE SPECIFIC ENOLASE and VMA.
Price: Contact Medilab
Turnaround time (TAT): 10 – 15 days
Usage: HVA and other catecholamine metabolites are elevated in patients with Neuroblastoma, Pheochromocytoma and other Neural crest tumors. This assay is useful for screening of catecholamine secreting tumors, monitoring Neuroblastoma treatment and evaluating patients with possible inborn errors of catecholamine metabolism.
Home Collection: Available
Pre-test Information: Patient should strictly avoid L-Dopa at least 72 hours before and during collection.