Specimen: 50 mL (10 mL min.) aliquot of 24-hour urine. Collect urine with appropriate volume of 50% HCl to maintain pH between 1–2. Do not use concentrated HCl. Record 24 hour volume on test request form and urine container. Ship refrigerated or frozen. Patient should strictly avoid Alpha- Methyldopa, Buspirone, Codeine, Isoproterenol metabolite, Mandelamine, L-dopa, Parcetamol, Metoclopramide, pepper, alcoholic beverages, tea/coffee, tobacco and strenuous exercise at least 72 hours before and during specimen collection.

Stability (Room): 8 hrs

Stability (Refrigerated): 5 days

Stability (Frozen): 30 days

Method: HPLC-EC

Comment: Initial testing for Pheochromocytoma should always include measurement of Plasma free or Urinary fractionated metanephrines. Recommended method for measurement is LC-MS/MS or HPLC-EC. Also see PHEOCHROMOCYTOMA PROFILE.

Price: Contact Medilab

Turnaround time (TAT): 10 – 15 days

Usage: This assay is useful as a screening test for the presumptive diagnosis of catecholamine secreting Pheochromocytoma & Paragangliomas. Metanephrine and Normetanephrine are 3-Methoxy metabolites of Epinephrine and Normetanephrine respectively. These are further metabolized to VMA. This assay may be used as a first order screening test.

Specialty: Oncologist

Disease: Cancer

Components: *Metanephrine *Normetanephrine

Courier Charges:

Home Collection: Available

Department: HPLC

Pre-test Information: Patient should strictly avoid Alpha- Methyldopa, Buspirone, Codeine, Isoproterenol metabolite, Mandelamine, L-dopa, Parcetamol, Metoclopramide, pepper, alcoholic beverages, tea/coffee, tobacco and strenuous exercise at least 72 hours before and during specimen collection.